Evolution of the genetic code. Emergence of stop codons
Denis A. Semenov
TL;DR
This paper explores how the genetic code evolved to include stop codons, proposing that a transition from GC to AGUC nucleotide alphabet explains their emergence during evolution.
Contribution
It introduces a hypothesis that the evolution from GC to AGUC nucleotide alphabet accounts for the appearance of stop codons in the genetic code.
Findings
Stop codons likely emerged during the transition from GC to AGUC alphabet.
The evolution of the genetic code involved the development of non-encoding codons.
The hypothesis explains the timing and mechanism of stop codon appearance.
Abstract
What could cause the emergence of non-encoding codons in the course of evolution of the genetic code? Hypothesis of evolution of the genetic code from GC to the AGUC-alphabet account for existence of stop codons.
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Taxonomy
TopicsRNA and protein synthesis mechanisms · Genomics and Phylogenetic Studies · Machine Learning in Bioinformatics