Loop-closure principles in protein folding

TL;DR

This paper reviews how loop closure principles serve as a fundamental physical concept in understanding protein folding rates and pathways, emphasizing their role in theoretical models.

Contribution

It highlights the significance of loop closure principles in protein folding, providing a theoretical perspective that enhances understanding of folding mechanisms.

Findings

Loop closure is a key physical principle in protein folding.

Theoretical models incorporating loop closure explain folding rates.

Loop closure principles help elucidate folding routes.

Abstract

Simple theoretical concepts and models have been helpful to understand the folding rates and routes of single-domain proteins. As reviewed in this article, a physical principle that appears to underly these models is loop closure.