Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

TL;DR

This study synthesizes a novel magnesium-porphyrazine compound, characterizes its liposomal formulations, and analyzes their physico-chemical properties to evaluate potential in anticancer therapy.

Contribution

It introduces a new magnesium-porphyrazine compound and provides detailed physico-chemical characterization of its liposomal delivery systems.

Findings

Successful synthesis and characterization of MgHECSPz

Liposomes with different surface charges were prepared

Structural analysis confirmed stable liposomal incorporation

Abstract

The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis- (1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20- porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and \zeta potential measurements in order to define the overall properties and structural details of loaded liposomes.