Intermittent dynamics and 1/f^beta noise in single cardiac muscle cells

TL;DR

This study reveals that the spontaneous beating activity of isolated cardiac cells exhibits intermittent dynamics with 1/f^beta noise, indicating intrinsic complex temporal behavior across multiple timescales.

Contribution

It demonstrates that 1/f^beta noise and power-law distributed interbeat intervals are inherent features of single cardiac cell activity, expanding understanding of cellular electrophysiological fluctuations.

Findings

Interbeat intervals follow a power-law distribution.

Autocorrelation shows 1/f^beta noise behavior.

Spontaneous activity exhibits heterogeneity and intermittency.

Abstract

Fluctuations in the spontaneous beating activity of isolated cardiac cells were studied over a timescale of six decades. The beat dynamics of single cardiac cells were heterogeneous and intermittent. The interbeat intervals (IBIs) were power-law distributed in a long-time regime. Furthermore, for long timescales up to the experimental window, the autocorrelation of IBIs exhibits a scaling behavior of 1/f^beta-noise type. These observations suggest that 1/f^beta noise is an intrinsic characteristic of spontaneous activity of single cardiac cells.