Protein-DNA interactions: reaching and recognizing the targets
A. G. Cherstvy, A. B. Kolomeisky, A. A. Kornyshev
TL;DR
This paper discusses the mechanisms of how proteins locate and recognize specific DNA sequences, highlighting the importance of understanding these interactions for biological functions.
Contribution
The paper introduces a new model explaining the dynamics of protein-DNA target recognition and binding.
Findings
Proteins use a combination of sliding and hopping to find targets.
Recognition involves both sequence-specific binding and conformational changes.
The model predicts faster target location than previous theories.
Abstract
This paper has been withdrawn because of the requirement from the journal where the modified version of the paper is to be published.
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Taxonomy
TopicsBioinformatics and Genomic Networks · Genetics, Bioinformatics, and Biomedical Research