A simple model for dynamic phase transitions in cell spreading

TL;DR

This paper proposes a simple phenomenological model to describe the dynamic phases of cell spreading, capturing macroscopic behaviors without detailed microscopic mechanisms like actin polymerization.

Contribution

It introduces a new, simplified model that explains the observed phases of cell spreading at the macroscopic level, bypassing complex microscopic details.

Findings

Model successfully reproduces observed spreading phases

Provides insights into cell motility dynamics

Simplifies understanding of cell-substrate interactions

Abstract

Cell spreading is investigated at various scales in order to understand motility of living cells which is essential for a range of physiological activities in higher organisms as well as in microbes. At a microscopic scale, it has been seen that actin polymerization at the leading edge of cell membrane primarily helps the cell to spread depending upon its extra-cellular environment which influences the polymerization process via some receptors on the cell membrane. There are some interesting experimental results at macroscopic scales (cell size) where people have observed various dynamic phases in terms of spreading rate of cell area adhering to the substrate. In the present paper we develop a very simple phenomenological model to capture these dynamic apparent phases of a spreading cell without going into the microscopic details of actin polymerization.