Effects of crosslinks on motor-mediated filament organization

TL;DR

This paper models how crosslinks influence motor-driven filament organization, revealing a transverse instability that causes dense filament bundles, aligning with observed cellular structures.

Contribution

It introduces a modified model incorporating crosslinks into motor-filament interactions, predicting new instability behavior and bundle formation.

Findings

Transverse instability leads to filament bundling.

Crosslinks suppress filament sliding, altering organization.

Model applies to multiple motor species configurations.

Abstract

Crosslinks and molecular motors play an important role in the organization of cytoskeletal filament networks. Here we incorporate the effect of crosslinks into our model of polar motor-filament organization [Phys. Rev. E {\bf 71}, 050901 (2005)], through suppressing the relative sliding of filaments in the course of motor-mediated alignment. We show that this modification leads to a nontrivial macroscopic behavior, namely the oriented state exhibits a transverse instability in contrast to the isotropic instability that occurs without crosslinks. This transverse instability leads to the formation of dense extended bundles of oriented filaments, similar to recently observed structures in actomyosin. This model also can be applied to situations with two oppositely directed motor species or motors with different processing speeds.