Universal spectrum for DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) genome

TL;DR

This study demonstrates that the distribution of CG base frequencies in Takifugu rubripes genome follows a universal inverse power law, indicating long-range correlations and suggesting functional significance of non-coding DNA.

Contribution

The paper applies a general systems theory based on statistical physics to show universal power law behavior in DNA base distributions, linking fractal fluctuations to genome structure.

Findings

CG base frequency distribution follows inverse power law.

Long-range correlations exist in non-coding DNA.

Non-coding DNA may contribute to genome function.

Abstract

The frequency distribution of DNA bases A, C, G, T exhibit fractal fluctuations ubiquitous to dynamical systems in nature. The power spectra of fractal fluctuations exhibit inverse power law form signifying long-range correlations between local (small-scale) and global (large-scale) perturbations. The author has developed a general systems theory based on classical statistical physics for fractal fluctuations which predicts that the probability distribution of eddy amplitudes and the variance (square of eddy amplitude)spectrum of fractal fluctuations follow the universal Boltzmann inverse power law expressed as a function of the golden mean. The model predicted distribution is very close to statistical normal distribution for fluctuations within two standard deviations from the mean and exhibits a fat long tail. In this paper it is shown that DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) Genome Release 4 exhibit universal inverse power law form consistent with model prediction. The observed long-range correlations in the DNA bases implies that the non-coding 'junk' or 'selfish' DNA which appear to be redundant, may also contribute to the efficient functioning of the protein coding DNA, a result supported by recent studies.