# A microfluidic device based on droplet storage for screening solubility diagrams

## TL;DR

This paper introduces a microfluidic device that rapidly screens solubility diagrams by storing nanoliter droplets with varying concentrations and applying temperature gradients, enabling quick and efficient phase diagram measurements.

## Contribution

The work presents a novel microfluidic platform for fast, high-throughput solubility diagram screening using droplet storage and temperature control.

## Key findings

- Measured ten points of the adipic acid solubility curve in under 1 hour.
- Used only 250 μL of solution for the entire process.
- Demonstrated direct, quantitative phase diagram reading.

## Abstract

This work describes a new microfluidic device developed for rapid screening of solubility diagrams. In several parallel channels, hundreds of nanoliter-volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 $\mu$L of solution.