Symmetries by base substitutions in the genetic code predict 2' or 3' aminoacylation of tRNAs

TL;DR

This paper uncovers symmetrical patterns in the genetic code through base substitutions, revealing how these symmetries predict the aminoacylation specificity of tRNAs at the 2' or 3' position.

Contribution

It introduces a novel framework of two-fold symmetries in the genetic code that links base substitutions to tRNA aminoacylation specificity.

Findings

Identifies complete sets of symmetries in the genetic code

Shows how base substitutions exchange properties of degeneracy and aminoacylation

Predicts tRNA aminoacylation sites based on symmetry patterns

Abstract

This letter reports complete sets of two-fold symmetries between partitions of the universal genetic code. By substituting bases at each position of the codons according to a fixed rule, it happens that properties of the degeneracy pattern or of tRNA aminoacylation specificity are exchanged.